This paper introduces the main contents of safety standardization, analyzes the safety standardization work in the process of nuclear power project construction and the typical weak links and problems in safety management, and puts forward various on-site management methods such as establishing safety management standard demonstration area, applying QA management function to do well in the independent management of construction contractor and contract evaluation, etc .That Implementation can improve the effect of safety production standardization effectively. The effective application of experience and measures can be carried out and applied in the industry widely, so as to promote the continuous improvement of safety management level.